Publications
You can always find an updated list of my publications on my Google Scholar profile.
39. Schorn M, Verhoeven S , Ridder L, Huber F, Acharya D, Aksenov A, Aleti G, Moghaddam JA, Aron A, Aziz S, Bauermeister A, Bauman K, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt A, Bode H, Boullie A, Brejnrod A, Bugni T, Calteau A, Cao L, Carrion V, Castelo-Branco R, Chanana S, Chase A, Chevrette M, Costa-Lotufo L, Crawford J, Currie C, Cuypers B, Dang T, de Rond T, Demko A, Dittmann E, Du C, Drozd C, Dujardin J, Dutton R, Edlund A, Fewer D, Garg N, Gauglitz J, Gentry E, Gerwick L, Glukhov E, Gross H, Gugger M, Matus DG, Helfrich E, Hempel BF, Hur JS, Iorio M, Jensen P, Kang KB, Kaysser L, Kelleher N, Kim CS, Kim KH, Koester I, König G, Leao T, Lee SR, Lee YY, Li X, Little J, Maloney K, Männle D, Martin C, McAvoy AC, Metcalf W, Mohimani H, Molina-Santiago C, Moore B, Mullowney M, Muskat M, Nothias LF, O’Neill E, Parkinson E, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez L, Sørensen S, Sosio M, Suessmuth R, Sweeney D, Tahlan K, Thomson R, Tobias NJ, Trindade-Silva A, van Wezel G, Wang M, Weldon K, Zhang F, Ziemert N, Duncan K, Crusemann M, Rogers S, Dorrestein P, Medema M, van der Hooft JJJ (2020) A community resource for paired genomic and metabolomic data mining. Nat Chem Biol (accepted).
38. Tobias NJ*, Eberhard FE, Guarneri AA. (2020) Enzymatic biosynthesis of B-complex vitamins is supplied by diverse microbiota in the Rhodnius prolixus anterior midgut following Trypanosoma cruzi infection. Comput Struct Biotechnol J. 2020 Nov 11;18:3395-3401. doi: 10.1016/j.csbj.2020.10.031. *corresponding author
37. Neubacher N*, Tobias NJ*, Huber M*, Cai X, Glatter T, Pidot SJ, Stinear TP, Lütticke A, Papenfort K, Bode HB (2020) Symbiosis, virulence and natural products biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat Microbiol 5(12):1481-1489. doi: 10.1038/s41564-020-00797-5 *equal first author
36. Mangas KM, Tobias NJ, Marion E, Babonneau J, Marsollier L, Porter JL, Pidot SJ, Wong CY, Jackson DC, Chua BY, Stinear TP (2020). High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice. PeerJ. 8:e9659. doi: 10.7717/peerj.9659.
35. Mangas KM, Buultjens AH, Porter JL, Baines SL, Marion E, Marsollier L, Tobias NJ, Pidot SJ, Quinn KM, Price DJ, Kedzierska K, Zeng W, Jackson DC, Chua BY, Stinear TP (2020). Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model. Infect Immun. 88(3):e00753-19. doi: 10.1128/IAI.00753-19.
34. Tobias NJ, Brehm J, Kresovic D, Brameyer S, Bode HB, Heermann R. (2020). New Vocabulary for Bacterial Communication. Chembiochem. doi: 10.1002/cbic.201900580
33. Tobias NJ*, Parra-Rojas C, Shi YN, Shi YM, Simonyi S, Thanwisai A, Vitta A, Chantratita N, Hernandez-Vargas EA*, Bode HB* (2019). Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand. Environ Microbiol (accepted). doi: 10.1111/1462-2920.14685 *co-corresponding author
32. Tobias NJ, Bode HB (2019). Heterogeneity in bacterial specialized metabolism. J Mol Biol (in press). doi: 10.1016/j.jmb.2019.04.042
31. Grammbitter GLC, Schmalhofer M, Karimi K, Shi YM, Schöner T, Tobias NJ, Morgner N, Groll M, Bode HB (2019). An uncommon type II PKS catalyzes biosynthesis of aryl polyene pigments. J Am Chem Soc. doi: 10.1021/jacs.8b10776
30. Shi YM, Brachmann AO, Westphalen MA, Neubacher N, Tobias NJ, Bode HB (2019). Dual phenazine gene clusters enable diversification during biosynthesis. Nat Chem Biol. 15(4):331-339.
29. Tobias NJ, Shi YM, Bode HB (2018). Refining the natural product repertoire in entomopathogenic bacteria. Trends Microbiol. 26(10):833-840
28. Tobias NJ, Linck A, Bode HB (2018). Natural product diversification mediated by alternative transcriptional starting. Angew Chem Int Ed Engl. 57(20):5699-5702
27. Bulltjens AH, Vandelannoote K, Meehan CJ, Eddyani M, de Jong BC, Fyfe JAM, Globan M, Tobias NJ, Porter JL, Tomita T, Tay EL, Seemann T, Howden BP, Johnson PDR, Stinear TP (2018). Comparative genomics shows that Mycobacterium ulcerans migration and expansion preceded the rise of Buruli ulcer in Southeastern Australia. Appl Environ Microbiol 84(8): e02612-17.
26. Tobias NJ, Wolff H, Djahanschiri B, Grundmann F, Kronenwerth M, Shi YM, Simonyi S, Grün P, Shapiro-Ilan D, Pidot SJ, Stinear TP, Ebersberger I, Bode HB (2017). Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nat Microbiol 2(12):1676-1685.
25. Muangpat P, Yooyangket T, Fukruksa C, Suwannaroj M, Yimthin T, Sitthisak S, Chantratita N, Vitta A, Tobias NJ, Bode HB, Thanwisai A (2017). Screening of the Antimicrobial Activity against Drug Resistant Bacteria of Photorhabdus and Xenorhabdus Associated with Entomopathogenic Nematodes from Mae Wong National Park, Thailand. Front Microbiol 8:1142.
24. Kaempfer P, Tobias NJ, Ke LP, Bode HB, Glaeser SP (2017). Xenorhabdus thuongxuanensis sp. nov. and Xenorhabdus eapokensis sp. nov., isolated from Steinernema species. Int J Syst Evol Microbiol 67(5):1107-1114.
23. Glaeser SP, Tobias NJ, Thanwisai A, Chantratita N, Bode HB, Kaempfer P (2016). Photorhabdus luminescens subsp. namnaoensis sp. nov. isolated from Heterorhabditis baujardi nematodes in Nam Nao district of central Thailand. Int J Syst Evol Microbiol 67(4):1046-1051.
22. Tobias NJ (2016). Insect vectors of disease: untapped reservoirs for new antimicrobials? Front Microbiol 7:2085.
21. Tobias NJ, Ahrendt T, Schell U, Miltenberger M, Hilbi H, Bode HB, 2016. Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp- type phosphopantetheinyl transferase. PeerJ 4:e2720.
20. Heinrich AK, Glaeser A, Tobias NJ, Heermann R, Bode HB, 2016. Heterogeneous regulation of anthraquinone biosynthesis via the novel regulator AntJ in Photorhabdus luminescens. Heliyon.2(11):e00197.
19. Tobias NJ, Heinrich AK, Eresmann H, Wright PR, Neubacher N, Backofen R, Bode HB, 2017. Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation of secondary metabolites. Environ Microbiol 19(1):119-129. doi: 10.1111/1462-2920.13502.
18. Tobias NJ, Mishra B, Gupta DK, Phan Ke L, Thines M, Stinear TP, Bode HB, 2016. Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle. BMC Genomics 17(1):537.
17. Tobias NJ, Amissah NA, Ahortor EK, Wallace JR, Ablordey AS, Stinear TP, 2016. Systematic fecal survey suggests peridomestic animals in rural Ghana are not major reservoirs of Mycobacterium ulcerans. PeerJ 4:e2065.
16. Schöner TA, Gassel S, Osawa A, Tobias NJ, Okuno Y, Sakakibara Y, Shindo K, Sandmann G, Bode HB, 2016. Aryl polyenes, one of the most widespread class of bacterial natural products, are functionally related to antioxidative carotenoids. Chembiochem 17(3):247-53.
15. Mulley G, Beeton ML, Wilkinson P, Ockendon-Powell N, Hapeshi A, Tobias NJ, Nollman FI, Bode HB, van den Elsen J, ffrench-Constant RH, Waterfield NR, 2015. From insect to man: Photorhabdus sheds light on the emergence of human pathogenicity. PLoS One 10(12): e0144937.
14. Schimming O, Challinor VL, Tobias NJ, Adihou H, Grün P, Pöschel L, Richter C, Schwalbe H, Bode HB, 2015. Structure, biosynthesis and occurrence of bacterial pyrrolizidine alkaloids. Angew Chem 54(43):12702-5.
13. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Dusterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kotter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nutzmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gomez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Hofte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Mendez C, Metsa-Ketela M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Muller R, Neilan BA, Nett M, Nielsen J, O’Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Sussmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glockner FO (2015) Minimum Information about a Biosynthetic Gene cluster. Nature chemical biology 11(9): 625-631
12. Gao W, Monk I, Tobias NJ, Galdman S, Seemann T, Stinear TP, Howden BP, 2015. Large tandem chromosome duplications facilitate niche adaptation during persistent infection with drug-resistant Staphylococcus aureus. MGen 1(2) DOI: 10.1099/mgen.0.000026.
11. Ablordey AS, Vandelannoote K, Frimpong IA, Amissah NA, Eddyani M, Durnez L, Portaels F, De Jonge B, Leirs H, Porter JL, Mangas K, Lam M, Buultjens A, Seemann T, Tobias NJ, Stinear TP, 2015. Spread of a Nigerian clone of Mycobacterium ulcerans in a Buruli ulcer endemic region of Ghana. PLoS Negl Trop Dis 9(3):e0003681.
10. Tobias NJ, Mishra B, Gupta DK, Phan Ke L, Thines M, Bode HB, 2015. Draft genome sequence of Ochrobactrum anthropi strain ML7 isolated from soil samples in the Vinhphuc province, Vietnam. Genome Announcements 3(2):e00218-15.
9. Dreyer A, Röltgen K, Dangy JP, Ruf MT, Scherr N, Bolz M, Tobias NJ, Moes C, Vettiger A, Stinear TP, Pluschke G, 2015. Identification of Mycobacterium ulcerans Protein MUL_3720 as a promising target for the development of a diagnostic test for Buruli ulcer. PLoS Negl Trop Dis 9(2):e0003477.
8. Amissah NA, Gryseels S, Tobias NJ, Ravadgar B, Suzuki M, Vandelannoote K, Durnez L, Leirs H, Stinear TP, Portaels F, Ablordey A, Eddyani M, 2014. Investigating the role of free-living amoebae as a reservoir for Mycobacterium ulcerans. PLoS Negl Trop Dis 8(9):e3148.
7. Lam MMC, Seemann T, Tobias NJ, Chen H, Haring V, Moore RJ, Ballard S, Grayson ML, Johnson PDR, Howden BP, Stinear TP, 2013. Fitter and faster: Insights from the complete genome sequence of an epidemic hospital ST203 clone of vancomycin-resistant Enterococcus faecium. BMC Genomics 14:595.
6. Porter JP, Tobias NJ, Pidot SJ, Falgner S, Tuck KL, Hong H, Leadley PF, Stinear TP, 2013. The membrane-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis. PLoS One 8(7):e70520.
5. Tobias NJ, Doig KD, Medema MH, Chen H, Haring V, Moore R, Seemann T, Stinear TP, 2013. Complete genome sequence of the frog pathogen Mycobacterium ulcerans ecovar Liflandii. J Bacteriol 195:556-564.
4. Pidot SJ, Porter JL, Tobias NJ, Anderson J, Catmull D, Seemann T, Kidd S, Davies JK, Reynolds E, Dashper S, Stinear TP 2010. Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation. Mol Microbiol 78(5):1216-1231.
3. Tobias NJ, Seemann T, Pidot SJ, Porter JL, Marsollier L, Marion E, Letournel F, Zakir T, Azuolas J, Wallace JR, Hong H, Davies JK, Howden BP, Johnson PD, Jenkin GA, Stinear TP, 2009. Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and Buruli ulcer. PLoS Negl Trop Dis 3(11):e553.
2. Porter JL, Tobias NJ, Hong H, Tuck KL, Jenkin GA, Stinear TP, 2009. Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum. Microbiology 155(6):1923-1933.
1. Pidot S, Tobias NJ, Stinear T: The pMUM Megaplasmid of Mycobacterium ulcerans and Closely Related Mycobacteria: A Blueprint for the Synthesis of Mycolactones. In: Microbial Megaplasmids. Edited by Schwartz E, vol. 11: Springer Berlin / Heidelberg; 2009: 283-296.